You should not use Timolol ophthalmic if you have asthma or severe COPD or severe heart disease (such as ‘sick sinus syndrome’, ‘second or third degree atrioventricular block’, severe heart failure, or very slow heartbeats). Side effects may occur if this medicine enters your bloodstream.
This medicine is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, such as the heart. This makes the heart beat slower and lowers blood pressure.
Timolol can be used alone or in combination with other glaucoma treatments such as B. bimatoprost, latanoprost, travoprost, tafluprost, brinzolamide, dorzolamide or brimonidine.
Next came apraclonidine, brand name Iopidine, sold by Alcon. I have done much of the clinical work on apraclonidine, a relatively selective alpha-2 agonist. It’s probably the safest drug we’ve seen in glaucoma therapy to date.
Reason for shortage
Bausch Health has a shortage of Timoptic-XE Ophthalmic Gelling Solution due to manufacturing delays. The company discontinued timolol gel-forming eye solution in September 2020.
The most common is timolol and is available as a generic, either 0.25% or 0.5%. Brand names like Timoptic and Timoptic-XE (Bausch + Lomb), Istalol (Bausch + Lomb) and Betimol (Akorn).
Hold the dropper directly over your eye and place one drop into the sachet as directed by your doctor, typically once in the morning or twice a day. Look down, gently close your eyes and place a finger in the corner of your eye (near your nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes.
The evaluation of the results shows that timolol reduces intraocular pressure by 31% in the long term. There were no changes in visual acuity, visual fields, cupping and degeneration of the optic disc, or slit-lamp examination findings.
Ophthalmic timolol significantly decreased resting and maximum exercise heart rates after the first dose and maximum exercise heart rates during chronic dosing.
The reason timolol and dorzolamide do not work at night explains Dr. Toris, is that both are aqueous humor suppressors; Aqueous flow normally decreases on its own at night, and the drug cannot cause it to decrease further.
The kinetics of protein aggregation were also altered in the presence of increasing concentrations of the drug, suggesting that long-term drug administration may contribute to the development of cataracts.
While the average eye pressure is approximately 15 mm Hg (millimeters of mercury), the range of normal eye pressure is much larger. About 90 percent of people fall between a pressure of 10 and 21. However, this does not mean that a blood pressure of 22 or more is abnormal.
Durysta is the first FDA-cleared delayed-release bimatoprost implant approved for patients with open-angle glaucoma and ocular hypertension. It is injected into the anterior chamber and settles at the lower angle.
Most ophthalmologists treat when the pressure is consistently higher than 28-30 mm Hg because of the high risk of damage to the optic nerve.
Remember, however, that glaucoma eye drops will not make you feel any different or improve your vision. They prevent your eyesight from deteriorating. If you don’t use them as directed, you may lose your eyesight.