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Does Aspirin React With Naoh?

FAQs Jackson Bowman August 1, 2022

This is a Acid-base reaction

Acid-base reaction
The reaction of an acid with a base is called a neutralization reaction. The products of this reaction are a salt and water. In this traditional representation, an acid-base neutralization reaction is formulated as a double exchange reaction.

in which the acetylsalicylic acid reacts with the base sodium hydr oxide to make the salt sodium acetylsalicylate and water (acid + base → salt + water).

Why NaOH is added to aspirin?

In the back titration of aspirin, a known excess of NaOH is added to the sample solution to ensure that both reactions have gone to completion.

What can react with NaOH?

Sodium hydroxide reacts with strong acids (hydrochloric, sulfuric or nitric acid), water and moisture to rapidly release heat. Sodium hydroxide reacts with metals (aluminium, lead, tin or zinc) to form flammable and explosive hydrogen gas.

What reacts with aspirin?

(A) Aspirin can easily enter cells and react with many different cellular chemicals. For example, aspirin can react with water to form the hydrolysis by-product salicylic acid. Aspirin can also react with nucleophilic metabolites (e.g. glutathione) or proteins to produce acetylated products.

Does salicylic acid dissolve in NaOH?

Closed 4 years ago. The chemistry lab note states that: 1) Aromatic acids such as benzoic acid and salicylic acid are NOT soluble in water. But they are soluble in 5% NaOH and 5% NaHCO3.

Is aspirin soluble in NaOH?

Aspirin would be easily soluble in NaOH as the carboxylic acid group would be deprotonated and thus negatively charged.

Is aspirin an acid or base?

Aspirin itself is an acid drug and causes gastric irritation and belching, which can lead to low oral pH [7].

Which of the following Cannot react with NaOH?

Solution: `C_(2)H_(5)OH` (Ethanol) is a very weak acid, so it does not react with NaOH.

What does not react with sodium hydroxide?

Aluminum does not react with sodium hydroxide.

Do all metals react with NaOH?

Only the metals whose oxides/hydroxides are amphoteric will react with strong water-soluble bases (alkalis) to liberate hydrogen gas.

What does aspirin dissolve in?

Aspirin is soluble in organic solvents such as ethanol, DMSO and dimethylformamide which should be purged with an inert gas. The solubility of aspirin in these solvents is approximately 80, 41, and 30 mg/mL, respectively.

Does aspirin react with water?

Aspirin (acetylsalicylic acid) reacts with water (eg, water in body fluids) to form salicylic acid and acetic acid, as shown in Figure 5.2. 2. Figure 5.2. 2: Hydrolysis of the aspirin reaction.

Can aspirin be dissolved in water?

There are several types of aspirin tablets including: Standard tablets that you swallow whole with water. dissolvable tablets that you dissolve in a glass of water.

Is aspirin a salicylic acid?

Aspirin was introduced into clinical practice more than 100 years ago. This unique drug belongs to a family of compounds called salicylates, the simplest of which is salicylic acid, the main metabolite of aspirin.

What solvent can dissolve salicylic acid?

Since salicylic acid is not sufficiently water soluble at room temperature to achieve the desired composition, it must be converted to salicylate. This can be done by reacting sodium bicarbonate (baking soda) with salicylic acid in water – the salicylic acid will dissolve during the reaction.

What dissolves salicylic acid?

Salicylic acid is notoriously difficult to dissolve. Salicylic acid powder is best dissolved with a mixture of alcohol, water and propylene glycol. If you find it difficult to find, vegetable oil is believed to be a good substitute for propylene glycol.

References:

  1. https://edu.rsc.org/download?ac=500794
  2. https://www.tn.gov/health/cedep/environmental/environmental-health-topics/eht/sodium-hydroxide.html
  3. https://www.researchgate.net/figure/Aspirin-chemical-reactivity-A-Aspirin-can-easily-enter-cells-and-react-with-many_fig2_262787876
  4. https://chemistry.stackexchange.com/questions/83280/solubility-experiment-of-different-organic-compounds
  5. https://study.com/academy/answer/is-aspirin-soluble-in-naoh-if-so-why-why-is-cannabinol-only-slightly-soluble-in-methyl-alcohol-at-room-temperature.html
  6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819276/
  7. https://www.doubtnut.com/question-answer-chemistry/which-of-the-following-will-not-react-will-naoh-52409912
  8. https://www.doubtnut.com/question-answer-chemistry/aluminium-does-not-react-with-sodium-hydroxide-112948319
  9. https://testbook.com/question-answer/metals-react-with-sodium-hydroxide-to-produce-____–5a4486a79832316e1e782e0f
  10. https://www.caymanchem.com/pdfs/70260.pdf
  11. https://chem.libretexts.org/Courses/University_of_California_Davis/UCD_Chem_002C/UCD_Chem_2C_(Larsen)/Text/05%3A_Chemical_Kinetics/5.02%3A_Reaction_Rates
  12. https://www.nhs.uk/medicines/aspirin-for-pain-relief/how-and-when-to-take-aspirin-for-pain-relief/
  13. https://pubmed.ncbi.nlm.nih.gov/11493722/
  14. https://communities.acs.org/t5/Ask-An-ACS-Chemist/Dissolving-salicylic-acid/td-p/11270
  15. https://procoal.co.uk/blogs/beauty/how-to-dilute-salicylic-acid-powder

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